Adult multiple sclerosis. Request an Appointment at Mayo Clinic. These tests are also used to rule out other conditions. Impact of multiple sclerosis relapses on progression diminishes with time. Journal of Neurology. A combination of genetics and environmental factors appears to be responsible. Journal of Clinical Neuroscience. Sweeney V. As with any observational study, unmeasured confounding remains possible. Interferon beta-1b in secondary progressive MS: This symptom often occurs when you stand up.